Introduction: Infectious disease is a primary cause of mortality in
Indonesian and also worldwide. At Dr. Soetomo Hospital Surabaya, the
infections caused by Staphylococcus aureus and Coagulase Negative
Staphylococcus showed increasing the prevalence of resistant against
ampicillin and gentamisin. Currently, in clinical practice, the dosage
of antimicrobial therapy adjusted based on M1C ( Minimal Inhibitory
concentration ) according to pharmacokinetic and pharmacodynamic
principles.
Objectives : To find the correlation between MIC and inhibitory zone
diameter of ampicillin or gentamicin respectively to two Gram positif
cocci bacteria namely Staphylococcus aureus or Coagulase Negative
Staphylococcus.
Method : Staphylococcus aureus and Coagulase Negative Staphylococcus
species were obtained from Clinical Microbiology Laboratory of Dr.
Soetomo Hospital Surabaya. Each isolal was examined using 2 methods,
namely dilution and disk diffusion according to the National Committee
for Clinical Laboratory Standard (NCCLS). The data were analyzed for
linier correlation regression between inhibitory zone diameter and MIC (
p< 0,05).
http://digilib.umm.ac.id/files/disk1/417/jiptumm-gdl-hidajahrac-20836-1-the8th-).pdf
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